NPR1 inhibitors: new drugs for itch treatment?

Liang Cao, Lixia Du, Hongzhen Hu

Abstract

In this issue of Science Translational Medicine, Solinski et al. (2019) (1) reported that pharmacological blockade of natriuretic peptide receptor 1 (NPR1), a receptor of neuropeptide natriuretic polypeptide b (NPPB), expressed by a subpopulation of mouse and human spinal cord neurons, may be the key to alleviate chronic itching. Further, the authors have identified small-molecule human NPR1 antagonists which could suppress chronic itch in mice without inducing significant adverse side effects.