Association of cytochrome P450 2C19 *2 and *3 variants with type 2 diabetes mellitus in Chinese population

Kai Chang, Yanhong Chen, Jie Xiong, Junlong Ren, Zhongyong Jiang


Background: Cytochrome P450 2C19 is a very important drug metabolizing enzyme. Meanwhile, CYP2C19 involved in the biosynthesis and metabolism of steroids, cholesterol, and other lipids. The current study aimed to estimate the association of CYP2C19 genotype with the risk of type 2 diabetes.
Methods: A total of 226 patients with glycometabolism disorder (GMD) and 349 volunteers with normal glucose metabolism (NGM) were genotyped for the CYP2C19 *1/*2/*3 using a BaiOTM gene microarrays system.
Results: CYP2C19 double mutation genotype (*2/*2, *3/*3, *2/*3) in the type 2 diabetes group are significantly higher than those in the GDWD group (χ2=12.729, P=0.000). CYP2C19 double mutation genotype was also an independent risk factor for type 2 diabetes (OR 4.960, 95% CI: 1.928–12.760, P=0.000).
Conclusions: It shows that double mutation genotype may be related to the type 2 diabetes susceptibility. Double mutation genotype was an independent risk factor for type 2 diabetes, and the risk of type 2 diabetes is five times higher than wild type and single mutation genotype. Furthermore, GMD cases with CYP2C19 double mutation genotype have a higher probability to deteriorate into type 2 diabetes.