Dp71 as a tumor suppressor: combined efforts of nuclear lamin B1 and emerin?

Being one of the largest pathogenic genes, the mutation of dystrophin results in Duchenne muscular dystrophy (DMD). Through alternative usages of internal promoters, Dp71 is a short isoform termed in accordance with its molecular mass, via undergoing alternative splicing of exons 71 and/or 78, Dp71 generate Dp71f (−71/−78) and Dp71d (−71/+78), the most studied isoforms. In Professor Bulmaro Cisneros original discovery, Dp71 was proved to take part in ion and water homeostasis, cell signaling, cell adhesion, and nuclear architecture, reviewed in (1).